Organic Synthesis of Aspirin Chemistry Formal Lab.

Experiment Four: Organic Synthesis of Aspirin

Abstract

The purpose of this experiment is to synthesise a common organic product called acetylsalicylic acetous (aspirin), and to occasion familiar with the optimum conditions needed for successful yields. Aspirin is produced from an acid catalyzed reaction between salicylic acid with acetic anhydride. The crystalline aspirin is synthesized and purified by recrystallization, although there is not a hundred share yield due to sources of error.

Introduction

Aspirin is a medicine commonly gear up in households around the world. It overly is one of the least everywherepriced and most usable drugs in the market. A Chemist named Felix Hoffmann start-off synthesized aspirin, otherwise known as acetylsalicylic acid, in 1897 from salicylic acid.1

Salicylic acid is a naturally formed substance. For ex antiophthalmic factorle, willow trees have been recognized since antiquated times as a natural source. Salicylic acid is lay out mainly in the willows leaves and bark. The pure acid possesses several useful medicinal properties. It is an antipyretic (a fever reducer), an analgesic (a pain reducer), and an anti-inflammatory (a swelling reducer).

Unfortunately, pure salicylic acid makes for a particularly unpleasant medicine. The salicylic acid molecule contains two acidic functional sorts, the hydroxybenzene group and the carboxylic acid group. These groups make salicylic acid pettish because it burns the sensitive linings of the mouth, throat, esophagus, and stomach. 2

These harsh qualities are alleviated by replacing the acidic hydrogens with less reactive groups of atoms: the acetyl group (COCH3). This results in acetylsalicylic acid or aspirin.

Acetylsalicylic acid is synthesized in labs and does not occur naturally. It is produced from adding acetic anhydride to salicylic acid in the charge of sulfuric acid (H2SO4), an acid catalyst: (Diagram from 1)

The impurities left over (unreacted salicylic acid, acetic acid and sulfuric acid) are removed by the process of...

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References

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I found the following order of reactivity for foursome catalysts in the synthesis of aspirin. I am not confident(predicate) if this order of activity is accurate, however.


Anhydrous sodium acetate < Boron trifluoride etherate < Pyridine < Concentrated sulfuric acid


I believe the H2SO4, sulfuric acid, is the best overall catalyst. I recall its used commercially (good and cheap).

Overall, this essay is an excellent example of what a formal lab report should look handle. All the selective information is accurate and this report has a strong introduction and discussion.

The referencing was also done correctly although when information is taken directly from a source it should be cited right in the report. I dont guess I saw that anywhere, but overall its a majuscule example of a proper formal lab report.

This is a good example of what a formal lab looks corresponding presented in the past tense. The back referencing to data was a loose perk. Many teachers like that. Regardless of whether you are doing a titular lab on aspirin or not this acquaint a good structure to what one should look like as far a structure.

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